They report that maximal suppression of the leukocyte and platelet counts occurs within 3 to 5 weeks and recovery within 4 to 8 weeks. Side effects of alkeran melphalan, warnings, uses rxlist. Melphalan is practically insoluble in water and has a pka. Melphalan is approved for palliative treatment of multiple myeloma ovarian epithelial cancer that cannot be removed by surgery melphalan is also being studied in the treatment of other types of cancer. Each singleuse vial contains melphalan hydrochloride equivalent to 50 mg melphalan and 20 mg povidone. Melphalan is used to treat multiple myeloma a type of blood cancer and cancer of the ovary. Alkeran for injection is reconstituted using the sterile diluent provided. Melphalan is a phenylalanine mustard that is available orally for treatment of multiple myeloma and carcinomas of the ovaries and breast. Melphalan fda prescribing information, side effects and uses. Fda label information for this drug is available at dailymed. Melphalan is in a class of medications called alkylating agents. Melphalan inhibits dna and rna synthesis via formation of interstrand cross links with dna, likely binding at the n.
Melphalan is also available in an injectable form for patients who cannot take melphalan by mouth. It is not known whether this drug is excreted in human milk. As a result, its cytotoxicity appears to be related to the extent of its interstrand crosslinking with dna, probably by binding at the n. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. For more information, see the drug information summary for melphalan hydrochloride. Osserman and takatsuki have used an initial course of 10 mgday for 7 to 10 days. Melphalan is an alkylating agent of the bischloroethylamine type. Melphalan, also known as lphenylalanine mustard, phenylalanine mustard, lpam, or lsarcolysin, is a phenylalanine derivative of nitrogen mustard.
Melphalan is also being studied in the treatment of other types of cancer. Melphalan is used to treat multiple myeloma a type of cancer of the bone marrow. History of chemotherapy era of modern chemotherapy began in early 1940s goodman and gilman first administered nitrogen mustard to patients with lymphoma. Melphalan is erratically absorbed from the gastrointestinal tract, and to overcome this pitfall, intravenous melphalan is utilized for the high doses prescribed for bone marrow transplant conditioning regimens. Melphalan is a pregnancy category d agent and may cause fetal harm when administered to a pregnant woman. Indicaciones terapeuticas y posologia melfalan contraindicaciones melfalan. Feb 01, 2020 melphalan is the active lisomer of the compound and was first synthesized in 1953 by bergel and stock. Alkeran melphalan, also known as lphenylalanine mustard, phenylalanine mustard, lpam, or lsarcolysin, is a phenylalanine derivative of nitrogen mustard. Women of childbearing potential should be advised to avoid becoming pregnant. Melphalan is a cancer medication that interferes with the growth and spread of cancer cells in the body. Melphalan resistant l1210 cells had impaired melphalan transport compared with the sensitive parent cells, but this alteration alone was not sufficient to fully account for the degree of resistance 38. Please use one of the following formats to cite this article in your essay, paper or report.
Melphalan is a bifunctional alkylating agent which is active against selective human neoplastic diseases. Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates dna at the n7 position of guanine and induces dna interstrand crosslinkages, resulting in the inhibition of dna and rna synthesis and cytotoxicity against both dividing and nondividing tumor cells. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020. Continuous orally maintenance therapy with 2 mgday is instituted. Oral cyclic melphalan and dexamethasone for patients with. Like other bifunctional alkylating agents, it is active against both. Longterm outcome after intensive therapy with etoposide, melphalan, total body. Nov 09, 2018 melphalan is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Melphalan, sold under the trade name alkeran among others, is a chemotherapy medication used to treat multiple myeloma, ovarian cancer, melanoma, and amyloidosis. Melphalan is used to treat multiple myeloma a type of. Alkeran for injection is supplied as a sterile, nonpyrogenic, freezedried powder. Dna crosslinks induced by melphalan in mouse leukemia l1210 cells were formed and. May 21, 2019 alkeran melphalan is a drug prescribed for the treatment of multiple myeloma and ovarian cancer. May 21, 2019 melphalan is the active lisomer of the compound and was first synthesized in 1953 by bergel and stock. Melphalan side effects, dosage, interactions drugs. To compare our experience with oral melphalandexamethasone. Melphalan, sold under the trade name alkeran among others, is a chemotherapy medication. Aug 23, 2018 please use one of the following formats to cite this article in your essay, paper or report.
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